Related Experiment Video
Updated: Aug 7, 2026
07:44
Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
[Pediatric neuro-oncology]
1Departmento de Pediatría, Universidad del País Vasco, Unidad de Oncología Pediátrica, Hospital de Cruces, Barakaldo, Vizcaya, Espana.
Revista De Neurologia
|July 14, 2006
Summary
Pediatric brain tumors are common and require early diagnosis and tailored treatments. Advances in neuro-imaging and genetic profiling improve survival rates for children with brain tumors.
Area of Science:
- Pediatric neuro-oncology
- Childhood brain tumor research
Context:
- Brain tumors are the most common solid tumors in children under 15.
- Advances in neuro-imaging enable earlier diagnosis.
- Pediatric oncology units utilize internationally based treatment protocols.
Purpose:
- Review unique characteristics of pediatric brain tumors compared to adult tumors.
- Provide incidence and survival data for pediatric brain tumors in Spain.
- Outline diagnostic strategies, imaging modalities, and treatment protocols stratified by risk markers.
Summary:
- Classification of brain tumors now includes biological, genetic, and molecular risk factors.
- Treatment must consider familial predisposition and tumor molecular markers.
- Focus on common pediatric brain tumor subtypes: gliomas, medulloblastomas/primitive neuroectodermal tumors, and ependymomas.
Impact:
- Early detection through imaging and biological techniques improves prognosis.
- Multicenter protocols in specialized units enhance treatment efficacy.
- Stratified treatments based on biological risk reduce morbidity and long-term effects.
Related Concept Videos
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...