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Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine
J Rivest1, K Despontin, L Ghys
1Unité de Dermatologie professionnelle et de l'Environnement, UCL 3033, Bruxelles, Belgique.
Dermatologica
|January 1, 1991
Abstract:
The peripheral H1-inhibiting effects of cetirizine 10 mg and ebastine 10 mg were compared at the skin level after single oral administration. The study was performed in 9 healthy subjects under double-blind randomized crossover conditions. Both drugs were significantly effective up to 24 h. The suppressive effect of cetirizine was significantly more rapid and more marked.