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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

[HIV infection]

Natsuo Tachikawa1

  • 1AIDS Clinical Center, International Medical Center of Japan.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 15, 2006
PubMed

HIV infection can cause the destruction of cellular immunity. Highly active antiretroviral therapy (HAART) has strong effects to HIV-1 and usually consists of three to four anti-HIV-1 drugs. HAART has caused dramatic change of prognoses in HIV-1 patients. But HAART has several problems to be overcome. IFN-alpha/beta also has anti-HIV-1 effects and single usage of IFN can cause reduction of plasma HIV RNA viral load with about 1 log10 copies/ml after two to eight weeks. IFN can function as an additional anti-HIV-1 drug experimentally, especially to primary or early phase patients and patients with multiple drug resistances.

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