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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
A new efficient route for the formation of quinoxaline N-oxides and N,N'-dioxides using HOF.CH3CN
1School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
Abstract:
HOF.CH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N'-dioxides in very good yields under mild conditions and short reaction times.
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