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Related Experiment Videos

Prevalence of postpartum thyroid dysfunction: a quantitative review.

Wanda K Nicholson1, Karen A Robinson, Robert C Smallridge

  • 1Department of Gynecology and Obstetrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA. wnichol@jhmi.edu

Thyroid : Official Journal of the American Thyroid Association
|July 15, 2006
PubMed
Summary
This summary is machine-generated.

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Postpartum thyroid dysfunction (PPTD) affects 1 in 12 women globally. Women with antithyroid peroxidase antibodies (TPOAbs) are 5.7 times more likely to develop PPTD.

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Public Health

Background:

  • Postpartum thyroid dysfunction (PPTD) prevalence estimates vary due to differing study designs and populations.
  • Accurate prevalence data is crucial for understanding the public health impact of PPTD.

Purpose of the Study:

  • To estimate the prevalence of PPTD in general and high-risk populations.
  • To analyze PPTD prevalence across geographical regions and in women with antithyroid peroxidase antibodies (TPOAbs).

Main Methods:

  • Systematic review and pooled analysis of published literature from 1975-2004.
  • Inclusion of 21 studies (8081 subjects) with data extraction by two independent reviewers.
  • Accounting for sample size, study quality, follow-up percentage, and screening duration.

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Main Results:

  • Pooled prevalence of PPTD in the general population was 8.1% (95% CI 6.6%-10.0%).
  • Women with TPOAbs had a pooled risk ratio of 5.7 (95% CI: 5.3-6.1) for developing PPTD.
  • Prevalence varied globally (4.4% in Asia to 5.7% in the US) and was higher in women with type 1 diabetes (19.6%).

Conclusions:

  • PPTD affects approximately 1 in 12 women worldwide, with higher risk in those with TPOAbs.
  • The high prevalence suggests routine screening for TPOAbs may be warranted, pending evaluation of benefits, costs, and risks.
  • Further research is needed to optimize screening and management strategies for PPTD.