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Tizanidine distribution in a postmortem case.

Jason H Sklerov1, Dawn E Cox, Karla A Moore

  • 1Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Bldg. 102, Rockville, Maryland 20850, USA.

Journal of Analytical Toxicology
|July 15, 2006
PubMed
Summary
This summary is machine-generated.

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A woman died from combined ethanol and multiple drug intoxication, specifically high levels of tizanidine. This case highlights the fatal potential of polydrug use, even with prescription medications.

Area of Science:

  • Forensic Toxicology
  • Clinical Pharmacology

Background:

  • This report details a case of fatal drug intoxication.
  • It involves a 57-year-old female found deceased with a suicide note.

Observation:

  • Autopsy revealed no significant findings.
  • Toxicological analysis detected ethanol (0.16 g/dL), diazepam (1.1 mg/L), and tizanidine (2.3 mg/L) in heart blood.

Findings:

  • The detected tizanidine blood concentration (2.3 mg/L) is significantly higher than levels typically seen with therapeutic use (≤0.025 mg/L).
  • The combined presence of ethanol and elevated levels of diazepam and tizanidine was identified as the cause of death.

Implications:

  • This case underscores the critical importance of comprehensive toxicological screening in post-mortem investigations.

Related Experiment Videos

  • It highlights the potential for severe toxicity and fatality from the combined ingestion of ethanol and prescription medications, even at levels not typically considered lethal individually.
  • Accurate interpretation of drug concentrations in the context of patient history and autopsy findings is crucial for determining cause and manner of death.