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Related Experiment Videos

Selenium losses in 10 burned patients.

M M Berger1, C Cavadini, A Bart

  • 1Anesthesiology, Centre Hospitalier Universitaire Vaudios (CHUV), CH-1011 Lausanne, Switzerland.

Clinical Nutrition (Edinburgh, Scotland)
|April 1, 1992
PubMed
Summary

Burn patients experience significant selenium (Se) losses, leading to deficiency. Measured losses, particularly operative wound losses, contributed to negative selenium balances, impacting serum levels and glutathione peroxidase activity.

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Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Burn Medicine

Background:

  • Severe burns cause significant physiological stress and nutrient depletion.
  • Selenium (Se) is an essential trace element crucial for antioxidant defense and immune function.
  • Understanding trace element losses is vital for optimizing nutritional support in burn patients.

Purpose of the Study:

  • To quantify selenium losses and assess selenium balance in patients with severe burns.
  • To investigate the relationship between selenium status and clinical outcomes post-burn.
  • To identify the primary routes of selenium loss in burn injury.

Main Methods:

  • Studied 10 burn patients (32% total body surface area burns) from post-injury day 1 to day 7.
  • Measured cutaneous selenium losses from wound dressings and exudates.

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  • Analyzed serum and urine samples for selenium levels and glutathione peroxidase activity until post-injury day 20.

    • Main Results:

    • Progressive decrease in exudative nitrogen losses observed.
    • Selenium was detected in wound seepage primarily during excision-grafting, with mean operative loss of 342 ± 191 μg.
    • Mean urinary selenium excretion was 41 ± 13 μg/24H, and operative cutaneous losses contributed to negative selenium balances.
    • Serum selenium and glutathione peroxidase (GSHPx) levels were depressed until post-injury day 20.
    • Serum selenium levels showed a significant correlation with nitrogen intake (p < 0.001).

    Conclusions:

    • Burn patients exhibit a selenium deficiency state, indicated by decreased serum Se and GSHPx levels.
    • Measured selenium losses, including operative wound losses, partially explain the negative balances but may underestimate total losses.
    • Limitations in measurement methods might prevent the detection of significant cutaneous selenium losses, suggesting potential underestimation of total Se depletion.