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Acute IGF-1 deficiency in multiple trauma victims.
M Jeevanandam1, N J Holaday, R F Shamos
1Trauma Center, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona, 85013, USA.
Clinical Nutrition (Edinburgh, Scotland)
|December 1, 1992
Summary
Nutritional support can restore Insulin-like Growth Factor-1 (IGF-1) levels post-trauma. However, obese or elderly patients show delayed IGF-1 recovery, requiring tailored treatment strategies.
Area of Science:
- Endocrinology
- Trauma Medicine
- Nutritional Science
Background:
- The catabolic state following severe injury is marked by reduced Insulin-like Growth Factor-1 (IGF-1) and elevated stress hormones.
- Factors like adiposity and aging negatively impact IGF-1 levels in both healthy and injured individuals.
Purpose of the Study:
- To assess the impact of nutritional support on circulating IGF-1 levels in multiple trauma victims.
- To investigate how patient characteristics (obesity, age) influence IGF-1 response to nutritional intervention.
Main Methods:
- Measurement of IGF-1 levels in trauma patients before and after 4 days of intravenous feeding.
- Analysis of correlations between IGF-1 levels, patient demographics (age, adiposity), and clinical status.
Main Results:
- Intravenous feeding successfully restored IGF-1 levels in non-obese, younger trauma patients.
- Obese and elderly patients exhibited a delayed or diminished IGF-1 response to nutritional support.
Conclusions:
- IGF-1 levels in trauma patients are influenced by nutritional status, age, and adiposity.
- The blunted IGF-1 response in obese and elderly trauma patients necessitates consideration in treatment planning.
- Adjuvant therapies may be beneficial for managing IGF-1 deficiency in specific patient subgroups post-trauma.