Related Experiment Video
Updated: Aug 7, 2026
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Venous thromboembolism in patients with diffuse large B-cell lymphoma
Rami S Komrokji1, Nikhil P Uppal, Alok A Khorana
1Department of Medicine, University of Cincinnati and Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45267-0501, USA. komrokrs@ucmail.uc.edu
Leukemia & Lymphoma
|July 15, 2006
Summary
Venous thromboembolism (VTE) affects 12.8% of diffuse large B-cell lymphoma (DLBCL) patients, often at diagnosis or during initial chemotherapy. This complication is linked to significantly worse survival outcomes in DLBCL patients.
Area of Science:
- Hematology
- Oncology
- Vascular Medicine
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Venous thromboembolism (VTE) is a known complication in cancer patients, but its frequency in DLBCL requires further elucidation.
Purpose of the Study:
- To determine the incidence of VTE in patients diagnosed with DLBCL.
- To identify risk factors associated with VTE in DLBCL.
- To assess the impact of VTE on survival in DLBCL patients.
Main Methods:
- Retrospective review of 211 DLBCL patient records from 1990-2001 at a tertiary care hospital.
- Exclusion of patients with transformed lymphoma, CNS lymphoma, HIV-related lymphoma, or incomplete records.
- Identification of symptomatic VTE events confirmed by imaging, occurring at diagnosis or during initial treatment.
Main Results:
- VTE occurred in 12.8% (27/211) of DLBCL patients.
- High International Prognostic Index (IPI) scores were associated with increased VTE risk; Stage I disease showed low risk.
- VTE was present at diagnosis in 37% and occurred during the first three chemotherapy cycles in 82% of affected patients.
- Median survival was significantly lower for patients with VTE (1.04 years) compared to those without (5.2 years).
Conclusions:
- VTE is a frequent complication in DLBCL, particularly occurring at diagnosis and during early chemotherapy.
- VTE in DLBCL patients is associated with a poorer prognosis and reduced survival.
- Risk stratification using factors like IPI may help identify DLBCL patients at higher risk for VTE.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:16Lymphatic Vessels and Lymph Transport
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...