Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detoxification: the basis of current practice.

A Foy1

  • 1Alcohol and Drug Services, Royal Newcastle Hospital, PO Box 664J, Newcastle, NSW, 2300, Australia.

Drug and Alcohol Review
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internal medicine in the bush: a clinical audit of a rural and remote outreach programme.

Internal medicine journal·2014
Same author

Marijuana 'bong' smoking and tuberculosis.

Internal medicine journal·2013
Same author

Primary hypothyroidism masquerading as hepatocellular necrosis.

QJM : monthly journal of the Association of Physicians·2013
Same author

Alcohol problems in a general hospital.

Addiction biology·2010
Same author

Circuit breakers for addiction.

Internal medicine journal·2007
Same author

Successful surgical treatment of protein-losing enteropathy complicating rheumatic tricuspid regurgitation.

Heart, lung & circulation·2007
Same journal

Use and Motivations for Consuming No and Low (NoLo) Alcohol Beverages Among US Adults 21 Years or Older.

Drug and alcohol review·2026
Same journal

The Detection of Novel Nitazene-Class Opioids in Unregulated Drug Markets in Canada.

Drug and alcohol review·2026
Same journal

How Have Alcohol Producers Changed the Alcohol Content of Their Products? A Descriptive Analysis of Reformulation in the Off-Trade Alcohol Market in Great Britain, 2018-2025.

Drug and alcohol review·2026
Same journal

Concurrent Use of Extra-Medical Medication for Opioid Use Disorder Among Adults Prescribed Methadone or Buprenorphine: A Cohort Study of Urban Adults Who Have Injected Drugs.

Drug and alcohol review·2026
Same journal

Payday Loan Use Among People With Lived and Living Experience of Substance Use.

Drug and alcohol review·2026
Same journal

Crossed Pathways: Tobacco-Cannabis Co-Use and Motivation to Quit in Young Adults in France.

Drug and alcohol review·2026
See all related articles

Chronic psychoactive drug use alters the central nervous system, reducing drug effectiveness and neuronal responsiveness. Detoxification aids the nervous system

Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Medicine

Background:

  • Chronic psychoactive drug use induces neuroadaptations in the central nervous system.
  • These changes affect neuronal responsiveness to both the drug and external stimuli.
  • Altered neuronal function can lead to diminished clinical effects and abnormal responses.

Purpose of the Study:

  • To elucidate the neurobiological changes associated with chronic psychoactive drug use.
  • To understand the process of nervous system recovery after drug cessation.
  • To define the critical role of detoxification in managing withdrawal and vulnerability.

Main Methods:

  • Review of neurobiological mechanisms underlying drug tolerance and dependence.
  • Analysis of neuronal plasticity following chronic substance exposure.

Related Experiment Videos

  • Examination of the physiological and psychological challenges during the withdrawal period.

    • Main Results:

    • Chronic drug use leads to significant alterations in central nervous system (CNS) responsiveness.
    • Neuronal adaptation reduces the perceived clinical effect of the drug.
    • Cessation of drug use initiates a natural healing process characterized by temporary abnormal responsiveness.

    Conclusions:

    • The central nervous system undergoes adaptive changes with chronic psychoactive drug use.
    • Nervous system recovery post-cessation is a gradual process, involving a period of vulnerability.
    • Detoxification is essential for safely navigating this recovery phase and mitigating risks.