Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classifying asthma.

LeRoy M Graham1

  • 1Morehouse School of Medicine, Georgia Pediatric Pulmonology Associates, PC, Suite 450, 1100 Lake Hearn Dr, Atlanta, GA 30342, USA. LMG254@aol.com

Chest
|July 15, 2006
PubMed
Summary
This summary is machine-generated.

Current asthma severity classification systems lack validation and struggle to assess treatment effectiveness. New methods focusing on inflammation and validated tools are needed for better asthma management and patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observations from the COVID-19 Pandemic.

Pediatric allergy, immunology, and pulmonology·2022
Same author

Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.

Annals of the American Thoracic Society·2019
Same author

Safety of tiotropium Respimat<sup>®</sup> in black or African-American patients with symptomatic asthma.

Respiratory medicine·2019
Same author

The impact of asthma exacerbations and preventive strategies.

Current medical research and opinion·2014
Same author

Primary care management of patients with asthma.

The Journal of family practice·2012
Same author

Racial disparities in pediatric asthma: a review of the literature.

Current allergy and asthma reports·2010

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • The National Asthma Education and Prevention Program and Global Initiative for Asthma guidelines utilize a widely accepted asthma severity classification.
  • This classification system, designed to guide therapy hierarchies, faces challenges in reliable physician application and lacks validation.
  • Crucially, it fails to assess asthma control post-treatment, despite symptom control being a primary therapeutic goal.

Purpose of the Study:

  • To highlight the limitations of current asthma severity classification systems.
  • To explore alternative and validated tools for assessing asthma control and disease progression.
  • To investigate the utility of measuring airway inflammation, such as eosinophilic inflammation, in asthma classification and treatment guidance.

Related Experiment Videos

Main Methods:

  • Review of existing asthma classification guidelines and their limitations.
  • Evaluation of validated tools for longitudinal assessment of asthma control.
  • Consideration of biomarkers like eosinophilic airway inflammation for clinical application.

Main Results:

  • The established severity classification is not validated and difficult to apply consistently.
  • Existing validated tools can provide longitudinal data on asthma control.
  • Eosinophilic airway inflammation shows potential for classifying asthma and guiding anti-inflammatory therapy, especially in specific patient subgroups.

Conclusions:

  • There is a need for improved, validated asthma classification methods that incorporate longitudinal control assessments.
  • Measuring airway inflammation, like eosinophilic inflammation, offers a promising approach for refining asthma classification and tailoring anti-inflammatory treatments (ICS therapy).
  • Development of user-friendly clinical tools for ongoing assessment of symptom control and disease progression is essential for effective asthma management.