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Related Experiment Videos

Side effects with inhaled corticosteroids: the physician's perception.

Richard S Irwin1, Naomi D Richardson

  • 1Pulmonary, Allergy and Critical Care Medicine Division, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. Irwinr@ummhc.org

Chest
|July 15, 2006
PubMed
Summary
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Physicians still worry about inhaled corticosteroid (ICS) side effects despite guidelines. Further research is needed to find ICS formulations, devices, and doses with the best risk-benefit balance for asthma management.

Area of Science:

  • Pulmonology
  • Pharmacology
  • Clinical Medicine

Background:

  • National Asthma Education and Prevention Program guidelines address inhaled corticosteroid (ICS) side effects.
  • Physicians express ongoing concerns about ICS local and systemic side effects, impacting patient adherence.
  • Widespread concerns persist regarding systemic effects like growth retardation and osteoporosis.

Purpose of the Study:

  • To highlight the need for continued research into inhaled corticosteroid (ICS) side effects.
  • To identify ICS formulations, devices, and doses offering an optimal risk/benefit ratio.
  • To address physician and patient reassurance regarding ICS safety in asthma management.

Main Methods:

  • Review of existing National Asthma Education and Prevention Program guidelines (1997, 2002).

Related Experiment Videos

  • Analysis of pharmacokinetic data showing varying systemic bioavailability of different ICS compounds and formulations.
  • Identification of a lack of clinical studies differentiating ICS formulations regarding side effect profiles.

    • Main Results:

    • Despite guidelines, significant physician concerns regarding ICS side effects persist.
    • Local side effects can lead to therapy discontinuation.
    • Systemic side effects, including growth issues and osteoporosis, remain a widespread concern.

    Conclusions:

    • Further understanding of ICS side effects is crucial.
    • Identifying optimal ICS formulations, devices, and doses is needed to balance risks and benefits.
    • Newer agents with improved safety profiles may alleviate physician and patient concerns about ICS therapy.