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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
Published on: September 9, 2015
Effect of dalbavancin on the normal intestinal microflora
Carl Erik Nord1, Gundars Rasmanis, Elisabeth Wahlund
1Department of Laboratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden. carl.erik.nord@ki.se
The Journal of Antimicrobial Chemotherapy
|July 15, 2006
Summary
Dalbavancin, a lipoglycopeptide antibiotic, showed minimal impact on the human intestinal microflora in healthy subjects. This study found no significant ecological disruption to the normal gut bacteria after dalbavancin administration.
Area of Science:
- Microbiology
- Pharmacology
- Gastroenterology
Background:
- Antibiotic administration can alter the delicate balance of endogenous microflora.
- Such alterations may lead to the colonization of pathogenic strains or the development of antibiotic resistance.
- Understanding the impact of new antibiotics like dalbavancin on gut flora is crucial.
Purpose of the Study:
- To investigate the effect of dalbavancin on the intestinal microflora of healthy human subjects.
- To assess potential ecological disruptions to the normal gut microbiome.
Main Methods:
- Twelve healthy adults received a single intravenous infusion of 1 g dalbavancin.
- Plasma and fecal samples were collected over several weeks for drug concentration and flora analysis.
- Fecal specimens were cultured to identify changes in bacterial populations and assess resistance.
Main Results:
- Dalbavancin was detected in plasma for up to 60 days and in feces for up to 14 days.
- Minor impacts were observed on Enterococci and Escherichia coli populations.
- No significant changes were noted in Lactobacilli, Clostridia, or Bacteroides; no resistant bacteria or Clostridium difficile were found.
Conclusions:
- Dalbavancin administration does not cause major ecological disturbances to the human intestinal microflora.
- The antibiotic appears to have a limited impact on the normal gut microbiome composition and function.
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