[Blood lipids in rats in an animal model of nephropathy]

The blood lipid spectrum of white Wistar rats was investigated in the course of modeling of electrolytic nephropathy. The changes of the serum lipid spectrum were characterized by the increase of triglycerides, total cholesterol, low density lipoprotein cholesterol, the index of atherogenity and by the reduction of high density lipoprotein cholesterol. The decrease of phosphatidylserine, the increase of phosphatidylethanolamine and sphingomyelin and higher degree of saturation of fatty acid composition were detected in the erythrocytic lipids in the blood of the experimental rats. Besides, the abnormalities concerning fatty acids transformations and severe disbalance between the precursors and the inhibitors of the synthesis of eicosanoids were established. The results of the above investigation provide the detection of metabolic disorders in particular components of lipid metabolism in experimental electrolytic nephropathy.