Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiplexed rectilinear ion trap mass spectrometer for high-throughput analysis.

Amy M Tabert1, Michael P Goodwin, Jason S Duncan

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA.

Analytical Chemistry
|July 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serine Octamer Substitution Reactions With α-Hydroxy Acids.

Rapid communications in mass spectrometry : RCM·2026
Same author

Molecular Framework Modification in Mass Spectrometry: Atom Exchange, Insertion, and Deletion.

Journal of the American Society for Mass Spectrometry·2026
Same author

Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules.

Analytical chemistry·2026
Same author

High-Throughput Small-Scale Platform for Synthesis, Characterization, and Modeling of Per- and Polyfluoroalkyl Substances Analogs.

Environmental science & technology letters·2026
Same author

Accelerated Synthesis of Pyrazoles Mediated by Water Microdroplets.

ACS sustainable chemistry & engineering·2026

A novel multichannel mass spectrometer enables high-throughput analysis of multiple samples simultaneously. This multiplexed rectilinear ion trap (RIT) instrument demonstrates efficient MS/MS and comparative mass spectra for screening applications.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Instrumentation

Background:

  • High-throughput analysis is crucial for modern screening applications.
  • Existing mass spectrometry techniques can be limited by sample throughput.
  • Rectilinear ion trap (RIT) analyzers offer potential for multiplexing.

Purpose of the Study:

  • To design and construct a multichannel mass spectrometer for simultaneous high-throughput analysis.
  • To evaluate the performance of a multiplexed RIT mass spectrometer.
  • To demonstrate the utility of differential data acquisition for comparative analysis.

Main Methods:

  • A multichannel mass spectrometer was built using four parallel RIT analyzers in a single vacuum chamber.
  • The instrument was operated with common control electronics, including a single RF amplifier.

Related Experiment Videos

  • Simultaneous mass spectra and MS/MS were acquired from multiple samples.

    • Main Results:

    • The multiplexed RIT mass spectrometer achieved simultaneous acquisition from four samples.
    • Excellent mass calibration linearity (R2 = 0.999 999) and a resolution of ~500 were obtained.
    • Simultaneous MS/MS and proof-of-principle for differential data acquisition were demonstrated.

    Conclusions:

    • The developed multichannel RIT mass spectrometer enables efficient, simultaneous analysis of multiple samples.
    • The instrument is suitable for high-throughput screening applications.
    • Differential data acquisition offers a method for comparative analysis, reducing data storage needs.