Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute sulfasalazine overdose.

A Minocha1, H A Dean, J E Mayle

  • 1Department of Medicine (Gastroenterology), Michigan State University, East Lansing.

Journal of Toxicology. Clinical Toxicology
|January 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Massive gastrointestinal bleeding associated with hookworm infestation in a child: case report.

Pediatric surgery international·2013
Same author

The global paediatric surgery network: early measures of interest in the website.

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2011
Same author

New insecticides for boll weevil, bollworm and aphid control.

Journal of economic entomology·2010
Same author

The relative toxicity of DDT and calcium arsenate to cotton leafworm.

Journal of economic entomology·2010
Same author

Despite high satisfaction, majority of gastro-oesophageal reflux disease patients continue to use proton pump inhibitors after antireflux surgery.

Alimentary pharmacology & therapeutics·2006
Same author

Postinfectious gastroparesis related to autonomic failure: a case report.

Neurogastroenterology and motility·2006

Sulfasalazine, a medication for inflammatory bowel diseases, has no previously reported overdoses. A young male survived a 25g overdose with prompt medical intervention and no adverse effects.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Toxicology

Background:

  • Sulfasalazine (salicylazosulfapyridine) is a widely prescribed medication for inflammatory bowel diseases (IBD).
  • Its safety profile is well-established, but data on overdose toxicity is lacking.
  • This case addresses a significant overdose scenario.

Observation:

  • A 23-year-old male intentionally ingested a large dose of sulfasalazine (25 grams).
  • The patient presented for medical evaluation following the overdose.
  • No prior reports of sulfasalazine overdose existed in medical literature.

Findings:

  • The patient received prompt medical treatment after the sulfasalazine ingestion.
  • Despite the substantial overdose, the patient experienced no adverse health effects.

Related Experiment Videos

  • This suggests a potentially higher tolerance to sulfasalazine overdose than previously assumed.

    • Implications:

    • This case highlights the importance of prompt medical care in overdose situations.
    • It provides initial data on the toxicological profile of a massive sulfasalazine dose.
    • Further research may be warranted to establish safe overdose limits for sulfasalazine.