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Updated: Aug 7, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Juxtaposed half-cystines as disulphide bridged partners in protein tertiary structure
Kunchur Guruprasad1, V Jai Kartik, T Lavanya
1Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India. guru@ccmb.res.in
Abstract:
Disulphide bridges involving juxtaposed half-cystines are observed in a number of protein three-dimensional structures analyzed from the Protein Data Bank. These disulphide bridges comprise a 'ring of 8-atoms' corresponding to Calpha1-C'-N-Calpha2-Cbeta2-Sgamma2-Sgamma1-Cbeta1-Calpha1 in the two half-cystines. The presence of such disulphide bridges introduces a 'bend' or 'kink' in the protein polypeptide chain.
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