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Updated: Aug 7, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Cyclooxygenases in cancer: chemoprevention and sensitization to conventional therapies
1Department of Obstetrics & Gynecology, College of Medicine, Seoul National University, 28 Yungun-dong, Jongno-gu, Seoul, 110-744, Korea.
Abstract:
We have focused on cyclooxygenase, the key enzyme in prostaglandin synthesis, from our basic knowledge regarding the enzyme, to its clinical application in the field of oncology. We will present evidence that this enzyme is intimately associated with carcinogenesis, invasion, metastasis, and the response of tumors to current therapeutic modalities in a variety of human malignancies. We will also discuss the applications of cyclooxygenase inhibitors to chemoprevention and to the sensitization of tumors to conventional anti-cancer therapies.
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