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Published on: November 7, 2018

Distribution of hepatitis B virus genotypes among patients with chronic infection

Nadia Regina Caldas Ribeiro1, Gubio Soares Campos, Ana Luiza Dias Angelo

  • 1Gastro-Hepatology Service, Federal University of Bahia and Hospital São Rafael, Bahia, Brazil.

Liver International : Official Journal of the International Association for the Study of the Liver
|July 18, 2006
PubMed

Insights

Hepatitis B virus (HBV) genotype A and F were most common in chronic infections in Brazil. No significant differences in genotype distribution were found across clinical HBV phases.

Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) exhibits significant global genetic diversity, with at least eight identified genotypes (A-H).
  • Understanding HBV genotype distribution is crucial for comprehending viral pathogenesis and epidemiological patterns, particularly in chronic infections.

Purpose of the Study:

  • To determine the prevalence and distribution of HBV genotypes among adult patients with chronic HBV infection in Salvador, Brazil.
  • To investigate potential correlations between HBV genotypes and different clinical phases of chronic infection, including HBV-DNA levels and serological markers.

Main Methods:

  • Adult patients with chronic HBV infection were consecutively evaluated in Salvador, Brazil.
  • Patients were categorized into chronic infection phases based on HBV-DNA levels and serum HBV markers.
  • HBV-DNA was detected and quantified using polymerase chain reaction (PCR); genotyping was performed via amino acid mutation analysis and phylogenetic analysis.

Main Results:

  • Of 114 evaluated patients, 96 had detectable HBV-DNA. Genotyping was performed on 76 isolates.
  • Hepatitis B virus genotype A (53/61) and genotype F (7/61) were the most prevalent among inactive HBsAg carriers.
  • Hepatitis B virus genotype A (10/12) and genotype F (2/12) were also dominant in patients with detectable HBeAg, elevated ALT, and high HBV-DNA levels.

Conclusions:

  • Hepatitis B virus genotypes A (subtypes adw2) and F (subtypes adw4) were the most frequently identified in this Brazilian cohort with chronic HBV infection.
  • No significant differences in genotype distribution were observed across various clinical phases of HBV infection or in relation to HBV-DNA levels.
  • The absence of HBV genotype D contrasts with previous findings in acute hepatitis B cases in the same region.
Abstract

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