Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular imaging promotes progress in orthopedic research.

Philipp Mayer-Kuckuk1, Adele L Boskey2

  • 1Bone Cell Biology and Imaging Laboratory, Hospital for Special Surgery, New York 10021, USA; Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

Bone
|July 18, 2006
PubMed
Summary

Molecular imaging allows noninvasive, real-time study of musculoskeletal tissues in living subjects. This technique is revolutionizing orthopedic research, from bone repair to arthritis, offering new diagnostic tools.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.

Nature cardiovascular research·2025
Same author

Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy.

Nature cardiovascular research·2024
Same author

Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.

EMBO molecular medicine·2021
Same author

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.

PLoS genetics·2020
Same author

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.

Scientific reports·2020
Same author

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.

Mammalian genome : official journal of the International Mammalian Genome Society·2020

Area of Science:

  • Orthopedic Research
  • Molecular Imaging
  • Musculoskeletal Biology

Background:

  • Understanding molecular mechanisms is crucial for musculoskeletal tissue development, maintenance, and health.
  • Recent genetic and proteomic discoveries require investigation in physiological conditions within living tissues.
  • Molecular imaging provides a noninvasive, quantitative, real-time method for studying biological processes in vivo.

Purpose of the Study:

  • To review molecular imaging techniques applicable to orthopedic research.
  • To present current applications of molecular imaging in bone and joint biology.
  • To highlight the potential of molecular imaging for preclinical research and clinical diagnostics.

Main Methods:

  • Summary of various molecular imaging modalities, including optical (bioluminescence, near-infrared fluorescence), nuclear, and magnetic resonance imaging.

Related Experiment Videos

  • Application of these techniques in murine models, including transgenic mice.
  • Monitoring of gene expression, protein degradation, cell migration, and cell death.

    • Main Results:

    • Molecular imaging has been successfully applied to study osteoblasts, stem cells, and bone phases (organic and mineral).
    • Investigations covered malignancy, injury, fracture healing, and cell/gene therapy for skeletal defects.
    • In joints, molecular imaging focused on inflammatory and destructive processes in arthritis.

    Conclusions:

    • Molecular imaging is a feasible and powerful strategy for diverse orthopedic research areas.
    • Its application is expected to increase, driving further research in musculoskeletal biology.
    • Molecular imaging holds significant promise for future preclinical orthopedic research and clinical musculoskeletal diagnostics.