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Updated: Aug 7, 2026
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Polymicrobial catheter sepsis in long term central venous catheters
N Williams1, G L Carlson, L Ganguli
1Nutrition Unit, University of Manchester, Hope Hospital, Eccles Old Road, Salford, M6 8HD, UK.
Clinical Nutrition (Edinburgh, Scotland)
|June 1, 1993
Summary
Catheter salvage attempts failed in two patients with polymicrobial catheter sepsis receiving home parenteral nutrition. Early catheter removal is recommended for these complex cases.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Vascular Access Devices
Background:
- Polymicrobial catheter sepsis poses a significant risk to patients reliant on long-term central venous catheters for home parenteral nutrition.
- Hemodynamic instability is a common presentation in patients with severe catheter-related bloodstream infections.
Purpose of the Study:
- To evaluate the efficacy of catheter salvage strategies in patients with polymicrobial catheter sepsis.
- To determine the optimal management approach for long-term central venous catheter sepsis in immunocompromised patients.
Main Methods:
- Case report of two patients with polymicrobial catheter sepsis.
- Administration of combined antibiotic and fibrinolytic therapy for catheter salvage.
- Monitoring of patient clinical status and hemodynamic stability.
Main Results:
- Catheter salvage attempts using combined antibiotic and fibrinolytic therapy were unsuccessful in both cases.
- Both patients experienced clinical deterioration despite salvage attempts.
- Catheter removal was ultimately required for both patients.
Conclusions:
- Catheter salvage should be approached with extreme caution in polymicrobial catheter sepsis.
- A low threshold for catheter removal is advised in patients with polymicrobial catheter sepsis and hemodynamic instability.
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