Related Experiment Video

Updated: Aug 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein(a) as a risk factor associated with ischemic heart disease: Ouro Preto Study

Ana Paula Carlos Cândido1, Silvania Ferreira, Angélica Alves Lima

  • 1Departamento de Farmácia, Universidade Federal de Ouro Preto, Rua Costa Sena 171, 35400-000 Ouro Preto, Minas Gerais, MG, Brazil.

Atherosclerosis
|July 18, 2006
PubMed

Insights

Lipoprotein(a) [Lp(a)] levels are linked to ischemic heart disease and cardiovascular risk factors in a Brazilian population. This study confirms Lp(a) as a significant factor in heart disease occurrence.

Area of Science:

  • Cardiology
  • Biochemistry
  • Epidemiology

Background:

  • Lipoprotein(a) [Lp(a)] is implicated as a cardiovascular disease risk factor.
  • Its independent role in cardiovascular disease remains debated in scientific literature.

Purpose of the Study:

  • To assess the association between serum Lp(a) levels and ischemic heart disease.
  • To investigate the relationship between Lp(a) and other cardiovascular risk factors in a Brazilian cohort.

Main Methods:

  • Serum Lp(a) levels were measured in 400 individuals from Ouro Preto, Brazil.
  • Analysis included lipid profile, blood glucose, anthropometric, and clinical parameters.
  • Multivariate analysis examined interactions between Lp(a), risk factors, and ischemic heart disease.

Main Results:

  • Serum Lp(a) levels showed a significant association with ischemic heart disease.
  • Lp(a) levels correlated with age, total cholesterol, LDL-cholesterol, and body fat percentage.
  • A strong association was observed between Lp(a) and the Framingham risk score (p=0.003).
  • Multivariate analysis identified significant interactions involving ischemic heart disease, sex, age, and total cholesterol.

Conclusions:

  • Serum Lp(a) levels are correlated with the occurrence of ischemic heart disease.
  • Lp(a) is associated with key cardiovascular risk factors, reinforcing its clinical significance.

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...