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Lipopolysaccharide and interleukin-1beta decrease sucrose intake but do not affect expression of place preference in

Susan J Larson1

  • 1Department of Psychology, Concordia College, 56562, Moorhead, MN 56562, USA. larson@cord.edu

Pharmacology, Biochemistry, and Behavior
|July 18, 2006
PubMed
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Immune system activation, triggered by LPS or IL-1beta, reduces intake of palatable solutions but not preference for associated environments. This highlights distinct effects on primary versus conditioned reinforcers.

Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Science

Background:

  • Immune system activation can diminish interest in rewarding stimuli.
  • Previous studies examined effects of cytokines and lipopolysaccharide (LPS) on behaviors reinforced by primary reinforcers like palatable solutions.
  • The current study investigates how immune activation impacts behaviors reinforced by both primary and conditioned reinforcers.

Purpose of the Study:

  • To determine if immune system activation differentially affects behaviors maintained by primary versus conditioned reinforcers.
  • To assess the impact of LPS and interleukin-1beta (IL-1beta) on sucrose intake (primary reinforcer) and conditioned place preference for sucrose (conditioned reinforcer).
  • To examine the influence of motivational state on conditioned place preference.

Main Methods:

Related Experiment Videos

  • Replication of findings showing immune activation decreases palatable solution intake.
  • Utilizing a conditioned place preference procedure in rats.
  • Administering LPS and IL-1beta to test effects on sucrose intake and sucrose-associated environment preference.
  • Manipulating motivational state (water deprivation vs. free access) to assess its effect on conditioned place preference.

Main Results:

  • Both LPS and IL-1beta significantly decreased sucrose intake, confirming effects on primary reinforcement.
  • Neither LPS nor IL-1beta affected the expression of a sucrose-induced place preference, indicating no impact on conditioned reinforcement.
  • A sucrose-induced place preference was observed in water-deprived rats but not in rats with free access to water, demonstrating sensitivity to motivational state.

Conclusions:

  • Immune system activation has differential effects on appetitive behaviors, specifically impacting primary reinforcers more than conditioned reinforcers.
  • The findings suggest that the neural pathways mediating primary and conditioned reinforcement may be differentially modulated by immune signals.
  • Conditioned place preference is a sensitive measure influenced by the subject's current motivational state.