Resting energy expenditure in cystic fibrosis as an indicator of disease severity
Related Experiment Video
Updated: Aug 7, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Tatiana Moudiou1, Assimina Galli-Tsinopoulou, E Vamvakoudis
14th Department of Pediatrics, Aristotle University of Thessaloniki, Agias Sofias 9, Pefka, 57010 Thessaloniki, Greece. tmod@med.auth.gr
Background:
An imbalance of energy expenditure has been reported in Cystic Fibrosis (CF). High-energy diets, in combination with pancreatic enzymes, do not always compensate for energy requirements. The aim of this study was to investigate the relation between Resting Energy Expenditure (REE) and disease severity in CF.
Methods:
REE was measured with indirect calorimetry in a group of 38 clinically stable CF patients (32 with pancreatic insufficiency and 6 with pancreatic sufficiency). Correlations between REE and pulmonary function as well as clinical status were studied.
Results:
Increased REE expressed as a percentage of predicted (REE%) was demonstrated in pancreatic insufficient CF patients (PI) (113.3+/-2.5%), as compared to pancreatic sufficient (98.9+/-2.5%) and healthy subjects. The elevated REE% in the PI group was not affected by gender and exhibited a strong correlation with the clinical status of the patients (r=-0.641).
Conclusions:
Our data analysis supports the argument that the percentage of predicted REE is an objective indicator of disease severity and progression as well as energy requirements in the assessment of CF patients.
More Related Videos
09:47Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
Published on: September 13, 2018
05:56Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Related Concept Videos
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History