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Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based

Richard F M Chin1, Brian G R Neville, Catherine Peckham

  • 1Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, UK. r.chin@ich.ucl.ac.uk

Lancet (London, England)
|July 18, 2006
PubMed

Insights

Childhood convulsive status epilepticus (CSE) is a common emergency with unique pediatric aspects. This study found CSE is more frequent and less deadly in children than adults, informing better management.

Area of Science:

  • Pediatric Neurology
  • Epidemiology
  • Emergency Medicine

Background:

  • Convulsive status epilepticus (CSE) is a leading pediatric neurological emergency.
  • Existing data primarily from adult populations may not reflect childhood CSE accurately.
  • The North London Status Epilepticus in Childhood Surveillance Study (NLSTEPSS) was initiated to provide a pediatric perspective.

Purpose of the Study:

  • To determine the incidence and characteristics of childhood CSE.
  • To establish a uniquely pediatric understanding of CSE.
  • To inform clinical management and resource allocation for pediatric CSE.

Main Methods:

  • A prospective, population-based surveillance study in North London.
  • Data collected via a clinical network using standardized proformas and medical records.
  • Capture-recapture modeling used to estimate ascertainment.

Main Results:

  • Estimated ascertainment of CSE episodes between 62% and 84%.
  • Ascertainment-adjusted incidence of 17-23 episodes per 100,000 children annually.
  • 1-year recurrence rate of 16%; case fatality rate of 3%.

Conclusions:

  • Childhood CSE is more common and less fatal than in adults.
  • Causes of pediatric CSE differ from adult populations.
  • Paediatric data are crucial for effective CSE management and resource allocation.
Abstract

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