Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Nodular mastocytosis.

Sarah Kasprowicz¹, I-Ja Chan, Daniel J Wall

¹Department of Dermatology, Rush University Medical Center, Chicago, IL 60612, USA. sarah_kasprowicz@rush.edu

Journal of the American Academy of Dermatology

|July 18, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-Of Concept Clinical Studies on the First 22 Tumors.

Journal of clinical medicine·2024

Same author

Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic (Spontaneous) Urticaria: A Meta-analysis of "Real-world" Evidence.

JAMA dermatology·2018

Same author

Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of 'real-world' evidence.

Expert opinion on biological therapy·2018

Same author

Validation and Banding of the ItchyQuant: A Self-Report Itch Severity Scale.

The Journal of investigative dermatology·2016

Same author

A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice.

Journal of dermatological science·2016

Same author

Clinicopathologic findings in (anti-FcepsilonR1alpha) autoimmune-related chronic urticaria.

Journal of cutaneous pathology·2015

This study details a rare case of nodular mastocytosis in a 70-year-old man, presenting with skin lesions, myelodysplastic syndrome, and a specific c-kit mutation. The findings highlight an unusual manifestation of mast cell proliferation.

Area of Science:

Hematology
Dermatology
Oncology

Background:

Mastocytosis is a rare disorder involving abnormal mast cell growth.
It can manifest in various forms, affecting skin and internal organs.

Observation:

A 70-year-old man presented with a rare form of nodular mastocytosis.
Symptoms included a widespread rash, disseminated nodular lesions, and ear pruritus with hearing loss.

Findings:

The patient was diagnosed with nodular mastocytosis, myelodysplastic syndrome, and a c-kit V560G mutation.
This specific genetic mutation is implicated in mast cell proliferation.

Implications:

This case expands the understanding of mastocytosis presentations.

Related Experiment Videos

It underscores the importance of genetic analysis in diagnosing rare mast cell disorders.

Further research may explore targeted therapies for c-kit mutations in mastocytosis.