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Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
Acute renal failure caused by renal infiltration by hematolymphoid malignancy
Steven E Lommatzsch1, Andrew M Bellizzi, Helen P Cathro
1Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA.
Annals of Diagnostic Pathology
|July 18, 2006
Summary
Malignant infiltration of the kidneys can cause acute renal failure (ARF). Chemotherapy improved ARF in a non-Hodgkin
Area of Science:
- Nephrology
- Oncology
- Hematology
Background:
- Renal involvement in malignancy can manifest as bilaterally enlarged kidneys.
- Acute renal failure (ARF) is a rare complication of malignant infiltrative processes affecting the kidneys.
Observation:
- Two cases of ARF secondary to malignant hematolymphoid infiltration are presented.
- Case 1: Non-Hodgkin's lymphoma infiltrating both kidneys led to ARF.
- Case 2: Plasma cell leukemia infiltrating kidneys resulted in dialysis dependence.
Findings:
- ARF in Case 1 resolved with chemotherapy, confirming the link to lymphoma infiltration.
- This is the first reported case of ARF due to documented renal infiltration by plasma cell leukemia.
- Renal failure in hematolymphoid malignancy has diverse causes, including direct infiltration.
Implications:
- Highlights the importance of considering malignant infiltration in patients with unexplained ARF and concurrent cancers.
- Underscores the spectrum of renal disease associated with plasma cell dyscrasias.
- Suggests potential for improved renal outcomes with timely diagnosis and treatment of renal infiltration.
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