Opening the cardiac chambers does not make any difference in p300 measurement
Ihsan Iskesen1, Hikmet Yilmaz, Funda Yildirim
1Department of Cardiovascular Surgery, Celal Bayar University School of Medicine, Manisa, Turkey. iskesen@yahoo.com
The Heart Surgery Forum
|July 18, 2006
Summary
Cognitive brain dysfunction after open heart surgery is common, with P300 auditory-evoked potentials showing temporary impairment. Full recovery of cognitive function is observed by 4 months post-surgery in both MVR and CABG patients.
Area of Science:
- Neurology
- Cardiology
- Surgical Complications
Background:
- Open heart surgery, particularly cardiopulmonary bypass (CPB), can lead to cognitive brain dysfunction.
- Potential causes include emboli and cerebral hypoperfusion during CPB.
Purpose of the Study:
- To objectively assess cognitive brain function after open heart surgery.
- To compare cognitive outcomes between mitral valve replacement (MVR) and coronary artery bypass grafting (CABG) patients.
Main Methods:
- Prospective study of 42 cardiac surgery patients (24 MVR, 18 CABG).
- Cognitive function measured using P300 auditory-evoked potentials pre-op, at 7 days, and 4 months post-op.
- Electroencephalographic evaluations were also performed.
Main Results:
- Preoperative P300 latencies showed no significant difference between MVR and CABG groups.
- At 7 days post-op, P300 latencies were significantly prolonged in both groups compared to pre-op values.
- P300 latencies nearly returned to baseline by 4-month follow-up, with no significant difference between groups.
Conclusions:
- Postoperative cognitive impairment, indicated by prolonged P300 values, was observed at 7 days but largely resolved by 4 months.
- No significant difference in cognitive outcomes was found between MVR and CABG patients.
