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MTHFR 677TT genotype increases the risk for cervical artery dissections
M Kloss1, T Wiest, S Hyrenbach
1Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, D69120 Heidelberg, Germany.
Journal of Neurology, Neurosurgery, and Psychiatry
|July 18, 2006
Summary
The methylene tetrahydrofolate reductase (MTHFR) C677T gene variant may slightly increase the risk of cervical artery dissection (CAD). This risk appears higher in patients experiencing multiple dissection events.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Science
Background:
- Cervical artery dissection (CAD) is a leading cause of stroke in young adults.
- The role of genetic factors, such as polymorphisms, in CAD etiology is under investigation.
Purpose of the Study:
- To investigate the association between the methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of cervical artery dissection (CAD) in a German population.
Main Methods:
- Genotyping for the MTHFR C677T polymorphism was performed on 174 German patients diagnosed with CAD.
- Patient data were compared with published data from 927 healthy German controls.
Main Results:
- The frequency of T alleles and TT genotype carriers was slightly elevated in CAD patients (13.8%) compared to healthy controls (10.6%).
- In patients with multiple dissection events (n=50), the TT genotype frequency was notably higher (18%) and correlated with the number of events.
Conclusions:
- The MTHFR C677T polymorphism may be a modifying factor for cervical artery dissection risk.
- Further research is warranted to elucidate the specific mechanisms linking MTHFR C677T to CAD pathogenesis.
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