Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

sgTarget: a target selection resource for structural genomics.

Ana P C Rodrigues1, Barry J Grant, Roderick E Hubbard

  • 1Structural Biology Laboratory, University of York York, YO10 5YW, UK.

Nucleic Acids Research
|July 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding.

Journal of medicinal chemistry·2026
Same author

The scientific legacy of Martin Karplus from the perspective of his collaborators.

Biophysical journal·2026
Same author

Targeting PTPN22 at Nonorthosteric Binding SitesA Fragment Approach.

ACS omega·2026
Same author

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.

Cell reports·2025
Same author

Design, modular synthesis and screening of 58 shape-diverse 3-D fragments.

Chemical science·2025
Same author

Editorial overview - New Concepts in Drug Discovery (2025).

Current opinion in structural biology·2025
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

sgTarget aids structural biologists in selecting protein targets for structure determination. This web resource identifies proteins lacking known structures and predicts their expression and crystallization potential.

Area of Science:

  • Structural Biology
  • Genomics
  • Bioinformatics

Background:

  • Structural genomics projects aim to determine protein structures on a large scale.
  • Identifying suitable protein targets for structure determination is a critical bottleneck.
  • Genomic data offers a vast resource for potential structural targets.

Purpose of the Study:

  • To introduce sgTarget, a web-based tool for selecting and prioritizing protein targets for structure determination.
  • To assist structural biologists in leveraging genomic data for their research needs.

Main Methods:

  • sgTarget annotates submitted gene or protein sequences.
  • It identifies sequence families with no known homologous structures.
  • The system characterizes proteins based on physicochemical properties influencing expression, solubility, and crystallization.

Related Experiment Videos

Main Results:

  • sgTarget provides summaries of analyses for individual sequences and datasets.
  • Users can select and rank sequence datasets based on customizable criteria.
  • The tool facilitates iterative target selection aligned with research objectives.

Conclusions:

  • sgTarget supports laboratories in structural and functional genomics projects.
  • The resource is valuable for structural biologists seeking to utilize genome sequences for structure determination.