Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ASGS: an alternative splicing graph web service.

Durgaprasad Bollina1, Bernett T K Lee, Tin Wee Tan

  • 1Department of Chemistry and Biomolecular Sciences and Biotechnology Research Institute, Macquarie University, Sydney, NSW 2109, Australia.

Nucleic Acids Research
|July 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TBM preferred to AlphaFold 3 for functional models of insect odorant receptors.

Computational and structural biotechnology journal·2026
Same author

Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration.

Briefings in bioinformatics·2025
Same author

Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood.

Nutritional neuroscience·2025
Same author

Biological databases in the age of generative artificial intelligence.

Bioinformatics advances·2025
Same author

Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions.

Scientific reports·2024
Same author

Pseudonormal Morphology of Salivary Gland Adenoid Cystic Carcinoma Cells Subverts the Antitumor Reactivity of Immune Cells: A Tumour-Cell-Based Initiation of Immune Evasion.

Cancer reports (Hoboken, N.J.)·2024

The Alternative Splicing Graph Server (ASGS) simplifies studying gene complexity by visualizing transcript diversity. This web tool generates splicing graphs to help researchers analyze alternative splicing events in eukaryotes.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Alternative splicing is a major source of complexity in higher eukaryotes.
  • Understanding transcript diversity is crucial for deciphering gene function and regulation.

Purpose of the Study:

  • To develop a web service for systematic study of alternatively spliced genes.
  • To provide a tool for compact visual representation of transcript diversity from a single gene.

Main Methods:

  • The Alternative Splicing Graph Server (ASGS) accepts transcripts in General Feature Format.
  • ASGS identifies reference and variable exons.
  • It generates transcript splicing graphs, exon summaries, splicing event classifications, and single-line graphs.

Related Experiment Videos

Main Results:

  • ASGS provides a systematic approach to analyze alternative splicing.
  • The generated splicing graphs offer a compact visual representation of transcript diversity.
  • The tool facilitates experimental analysis of alternatively spliced genes.

Conclusions:

  • ASGS is a valuable, freely available web resource for researchers studying alternative splicing in higher eukaryotes.
  • The server aids in understanding gene complexity arising from transcript diversity.