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Updated: Aug 7, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences
Areum Han1, Hyo Jin Kang, Yoobok Cho
1National Genome Information Center (NGIC), Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-guDaejeon 305-333, Korea.
Abstract:
The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNP@Domain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNP@Domain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.
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