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Breast biopsy nuclear pellets are a convenient source of DNA for routine determination of Her-2/neu gene
O Malka1, Y Pollack, D Benharroch
1Department of Oncology, Soroka Medical Center, Beer-Sheva, Israel.
Breast Cancer Research and Treatment
|September 1, 1991
Abstract:
Cell nuclei from breast biopsies are a byproduct of routine hormone receptor determination and are usually discarded. We report here that DNA purified from this source is suitable for use in conventional Southern blot or Polymerase Chain Reaction (PCR) techniques to screen for Her-2/neu amplification, enabling efficient use of limited biopsy material.