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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
The course of melanoma-associated vitiligo: report of a case
Maryam Daneshpazhooh1, Ali Shokoohi, Ali Dadban
1Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran. daneshpj@sina.tums.ac.ir
Abstract:
The appearance of vitiligo-like lesions in patients with malignant melanoma is a well-known yet uncommon phenomenon. This finding is especially reported in patients undergoing immunotherapy with or without chemotherapy for malignant melanoma and is generally believed to be associated with a better prognosis. We report a case of preexisting vitiligo in a 48-year-old man, aggravated after chemo-immunotherapy of pulmonary metastatic melanoma with interferon-alpha, vinblastine and dacarbazine. Skin lesions remained stable after discontinuation of the treatment, and repigmentation heralded the recurrence of metastatic disease. These findings were in favor of vitiligo being a marker of the immunity against melanoma cells and its favorable impact on the prognosis of melanoma patients.
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