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[Beta blockers and corneal sensitivity].

H Höh1, W Nastainczyk

  • 1Universitäts-Augenklinik, Universität, Homburg/Saar, Bundesrepublik Deutschland.

Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|January 1, 1991
PubMed
Summary

Beta blockers vary significantly in their local anesthetic effects, impacting eye comfort. Increased anesthetic effect correlates with decreased topical tolerability, necessitating corneal sensitivity monitoring during treatment.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Beta blockers are widely used for various ophthalmic conditions.
  • Their local anesthetic effects and topical tolerability can differ significantly.
  • Understanding these differences is crucial for patient management.

Purpose of the Study:

  • To evaluate the local anesthetic effect and topical subjective tolerability of various beta blockers.
  • To investigate the relationship between anesthetic effect, tolerability, and physicochemical properties.

Main Methods:

  • Conducted placebo-controlled, randomized, prospective, parallel, double-masked studies.
  • Assessed local anesthetic effects and subjective tolerability in healthy individuals.
  • Correlated findings with the octanol-water distribution coefficient.

Main Results:

  • Marked variations in local anesthetic effects were observed among different beta blockers.
  • Stronger anesthetic effects were associated with decreased subjective tolerability.
  • A statistically significant correlation was found between anesthetic effect, tolerability, and the octanol-water distribution coefficient.

Conclusions:

  • The local anesthetic effect is a critical factor in beta blocker selection and differential indications.
  • Regular monitoring of corneal sensitivity is recommended, especially for sensitive eyes, contact lens wearers, and during therapy with potent anesthetic beta blockers.

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