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Published on: March 15, 2022
Coronary heart disease care in older women: optimizing diagnostic and therapeutic decisions
Mori J Krantz1, Bonnie A Leeman-Castillo, Karol E Watson
1Department of Medicine, Denver Health, University of Colorado Health Sciences Center, USA.
Insights
Older women with coronary heart disease (CHD) face unique challenges. This review synthesizes evidence on optimal diagnostic and therapeutic strategies for this population.
Area of Science:
- Cardiology
- Geriatric Medicine
- Women's Health
Background:
- Cardiovascular disease (CVD) is a leading cause of death and morbidity in women.
- Coronary heart disease (CHD) risk increases with age.
- Women have been historically underrepresented in CHD clinical trials.
Purpose of the Study:
- To synthesize current evidence on optimal diagnostic and therapeutic approaches for older women with established CHD.
- To highlight differences in CHD presentation and management between older women and men.
Main Methods:
- Review of current evidence and guidelines.
- Synthesis of data on diagnostic performance and treatment outcomes.
- Analysis of age- and sex-specific factors in CHD management.
Main Results:
- Older women with CHD present differently than men.
- Diagnostic tests for cardiac stress may have varying performance in older women.
- Older women may face different risks from coronary revascularization procedures.
- Evidence-based lifestyle and pharmacologic interventions show similar benefits in men and women, and older patients.
Conclusions:
- Optimal CHD care for older women requires consideration of sex- and age-specific differences.
- Further research is needed to optimize diagnostic and therapeutic strategies for this demographic.
- Adherence to evidence-based guidelines is crucial for improving outcomes in older women with CHD.
Abstract:
Cardiovascular disease is the leading cause of death and morbidity among women. The prevalence of coronary heart disease (CHD) and its attendant risk clearly increase with advancing age. Though traditionally underrepresented in CHD trials, the proportion of women participating in these studies has risen in recent years. The American Heart Association has recently published statements on the optimal CHD care for both the elderly and female populations. Evidence-based life style and pharmacologic interventions for CHD appear to offer similar benefits in men and women as well as for older patients. However, older women with CHD differ from men in symptoms, the diagnostic performance of cardiac stress tests, the risk of complications from coronary revascularization procedures, and use of proven beneficial therapies. This article synthesizes the current state of the evidence on optimal diagnostic and therapeutic approaches to older women with established CHD.
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