Related Experiment Video
Updated: Aug 7, 2026
11:32
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
Versican: signaling to transcriptional control pathways
Maziar Rahmani1, Brian W Wong, Lisa Ang
1The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, BC, Canada.
Canadian Journal of Physiology and Pharmacology
|July 19, 2006
Summary
This review explores the transcriptional control of versican gene regulation, a key extracellular matrix proteoglycan. Understanding versican
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Versican is a major extracellular matrix proteoglycan involved in development and disease.
- It plays roles in cell adhesion, proliferation, migration, and angiogenesis.
- Dysregulation of versican is implicated in diseases like cancer and atherosclerosis.
Purpose of the Study:
- To review the current knowledge of versican gene regulation at the transcriptional level.
- To understand the complex biosynthetic processing of versican.
- To correlate versican's expression patterns with its functional roles in development and pathology.
Main Methods:
- Literature review focusing on transcriptional control mechanisms.
- Analysis of signal transduction pathways influencing versican expression.
- Examination of promoter regions, cis-acting elements, and trans-acting factors.
Main Results:
- Versican gene regulation involves intricate signal transduction pathways.
- Specific promoter regions and cis-acting elements are crucial for versican expression.
- Various trans-factors modulate versican's temporal and spatial expression patterns.
Conclusions:
- A comprehensive understanding of versican transcriptional control is essential for appreciating its roles.
- Further research into versican gene regulation can inform therapeutic strategies for related diseases.
- Knowledge of versican's complex regulation is key to understanding its multifaceted functions.
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