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Updated: Aug 7, 2026

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
Published on: October 28, 2022
[Permeability research of human temporomandibular joint disc and cartilage]
Xiao-Chuan Xu1, Meng-Shi Chen, Xin-Zhu Yi
1Beijing Research Institute of Traumatology and Orthopedics, Beijing 100035, China.
Objective:
To measure the permeability of human temporomandibular joint (TMJ) disc and cartilage to provide basic parameter for oral biomechanics and tissue engineering, and analyze its mechanisms of pathology and load-release.
Methods:
Confined compression method was used to measure the permeability (k value) of four cadavers' TMJs, which were sampled into three parts: disc, condyle and glenoid fossa with different diameters (2 mm, 3 mm and 4 mm). All 128 samples were tested with correspond diameter indenter.
Results:
Larger the sample diameter was, higher the k value became. The highest k value appeared in the disc while the lowest appeared in glenoid fossa.
Conclusion:
In normal condition, TMJ can suffer huge load by decreasing its permeability. Disc is weakest for the higher permeability, it's easy-damaged region is an initiated factor of TMJ disease.

