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[Thyroid C cells are decreased in experimental CDH].

L Martínez1, M De Ceano-Vivas, S González-Reyes

  • 1Departamento de Cirugía Pediátrica, Hospital Universitario La Paz, Madrid. lmartinezm.hulp@saludm.madrid.org

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|July 19, 2006
PubMed
Summary

Exposure to nitrofén significantly reduced thyroid C-cells and altered their distribution in rats with congenital diaphragmatic hernia (CDH). This suggests neural crest dysregulation in CDH pathogenesis.

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Area of Science:

  • Developmental biology
  • Endocrinology
  • Teratology

Background:

  • Congenital diaphragmatic hernia (CDH) is linked to neural crest malformations.
  • Human CDH shares features with experimental models, suggesting common pathogenic mechanisms.
  • Thyroid C-cells, derived from neural crest, are investigated for abnormalities in CDH.

Purpose of the Study:

  • To investigate thyroid C-cell abnormalities in a rat model of experimental CDH.
  • To determine if nitrofén exposure affects C-cells in CDH fetuses.

Main Methods:

  • Pregnant rats were exposed to nitrofén or vehicle on day 9.5 of gestation.
  • Thyroids from day 21 fetuses with CDH were immuno-histochemically stained for calcitonin.
  • C-cell number and distribution were quantified using image analysis and compared between groups.

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Main Results:

  • CDH rats exhibited a significant reduction in thyroid C-cells compared to controls (p<0.0001).
  • C-cell distribution was abnormal in CDH rats, with cells tending towards the periphery.
  • Thyroid histology was similar between CDH and control groups.

Conclusions:

  • Nitrofén exposure in rats with experimental CDH leads to decreased C-cells and altered distribution.
  • Findings support the role of neural crest dysregulation in CDH pathogenesis.
  • Further research is warranted to explore potential clinical relevance in human CDH.