Related Experiment Video
Updated: Aug 7, 2026
Single Port Donor Nephrectomy
Published on: March 12, 2011
Comparison of laparoscopic and mini incision open donor nephrectomy: single blind, randomised controlled clinical
Niels F M Kok1, May Y Lind, Birgitta M E Hansson
1Department of Surgery, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, Netherlands.
Objectives:
To determine the best approach for live donor nephrectomy to minimise discomfort to the donor and to provide good graft function.
Design:
Single blind, randomised controlled trial.
Setting:
Two university medical centres, the Netherlands.
Participants:
100 living kidney donors.
Interventions:
Participants were randomly assigned to either laparoscopic donor nephrectomy or to mini incision muscle splitting open donor nephrectomy.
Main Outcome Measures:
The primary outcome was physical fatigue using the multidimensional fatigue inventory 20 (MFI-20). Secondary outcomes were physical function using the SF-36, hospital stay after surgery, pain, operating times, recipient graft function, and graft survival.
Results:
Conversions did not occur. Compared with mini incision open donor nephrectomy, laparoscopic donor nephrectomy resulted in longer skin to skin time (median 221 v 164 minutes, P < 0.001), longer warm ischaemia time (6 v 3 minutes, P < 0.001), less blood loss (100 v 240 ml, P < 0.001), and a similar number of complications (intraoperatively 12% v 6%, P = 0.49, postoperatively both 6%). After laparoscopic nephrectomy, donors required less morphine (16 v 25 mg, P = 0.005) and shorter hospital stay (3 v 4 days, P = 0.003). During one year's follow-up mean physical fatigue was less (difference - 1.3, 95% confidence interval - 2.4 to - 0.1) and physical function was better (difference 6.2, 2.0 to 10.3) after laparoscopic nephrectomy. Function of the graft and graft survival rate of the recipient at one year censored for death did not differ (100% after laparoscopic nephrectomy and 98% after open nephrectomy).
Conclusions:
Laparoscopic donor nephrectomy results in a better quality of life compared with mini incision open donor nephrectomy but equal safety and graft function.
