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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[Molecular dialogue between African trypanosomes and humans].

Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
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Organization of telomeres during the cell and life cycles of Trypanosoma brucei.

The Journal of eukaryotic microbiology·2002
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An update on antigenic variation in African trypanosomes.

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A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule.

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Related Experiment Video

Updated: Jul 28, 2026

Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy
09:37

Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy

Published on: August 15, 2014

The function of apolipoproteins L.

B Vanhollebeke1, E Pays

  • 1Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, 6041 Gosselies, Belgium.

Cellular and Molecular Life Sciences : CMLS
|July 19, 2006
PubMed
Summary

The apolipoprotein L (apoL) family

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • The functions of apolipoprotein L (apoL) proteins are largely unknown.
  • Apolipoprotein L-I (apoL-I) is secreted and associated with high-density lipoprotein particles.
  • Other apoL family members are thought to be intracellular.

Purpose of the Study:

  • To explore the functions of the apolipoprotein L family.
  • To investigate the potential roles of apoLs in ion channel formation and programmed cell death.

Main Methods:

  • Comparative analysis of apoL proteins with Bcl-2 family proteins.
  • Review of existing literature on apoL-I's trypanosome-killing mechanism.
  • Analysis of evidence for apoL expression modulation in pathological processes.

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Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening
07:37

Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening

Published on: May 13, 2020

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Related Experiment Videos

Last Updated: Jul 28, 2026

Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy
09:37

Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy

Published on: August 15, 2014

Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening
07:37

Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening

Published on: May 13, 2020

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Main Results:

  • Apolipoprotein L proteins share structural and functional similarities with Bcl-2 family proteins.
  • ApoL-I has a demonstrated mechanism for killing African trypanosomes.
  • Evidence suggests apoL expression is modulated in various diseases.

Conclusions:

  • Apolipoprotein L proteins may function as ion channels in intracellular membranes.
  • ApoLs are potentially involved in initiating programmed cell death pathways.
  • Further research is needed to elucidate the specific roles of apoL family members.