Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropeptides as synaptic transmitters.

Chiara Salio1, Laura Lossi, Francesco Ferrini

  • 1Dipartimento di Morfofisiologia Veterinaria and Rita Levi Montalcini Center for Brain Repair, Via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.

Cell and Tissue Research
|July 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in the cortical GABAergic inhibitory system in a Spinal Muscular Atrophy mouse model.

Cell death & disease·2026
Same author

Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy.

Communications biology·2026
Same author

From Ornamental Value to Antioxidant Activity: Comparative Phytochemistry of <i>Lavandula</i> Species and Cultivars.

Metabolites·2026
Same author

Valorisation of mediterranean basin fruit by-products: bioactive composition, applications, and future research directions.

Natural product research·2025
Same author

Editorial: Methods in cellular neurobiology research.

Frontiers in cellular neuroscience·2025
Same author

Cultivar-specific responses of young olive trees to water deficit: impacts on physiology, leaf anatomy, and fruit quality in 'Arbequina', 'Leccio del Corno' and 'Maurino'.

Plant physiology and biochemistry : PPB·2025
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Neuropeptides are signaling molecules found in neurons that coexist with neurotransmitters. Their storage in vesicles and unique release mechanisms enable slow neuronal communication.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Neuropeptides are small protein molecules (3-100 amino acids) found in specific neuronal populations.
  • They often coexist with classical low-molecular-weight neurotransmitters within the same neurons.
  • Subcellular localization reveals selective storage in large granular vesicles, individually or in combinations.

Purpose of the Study:

  • To elucidate the storage, release, and functional significance of neuropeptides in neuronal communication.
  • To understand how subcellular localization influences neuropeptide function.
  • To explore the role of neuropeptide coexistence with neurotransmitters.

Main Methods:

  • Localization studies of neuropeptides within neuronal populations.

Related Experiment Videos

  • Investigation of subcellular storage mechanisms (large granular vesicles).
  • Analysis of neuropeptide release pathways distinct from classical exocytosis.

    • Main Results:

    • Neuropeptides are selectively stored in large granular vesicles, often in combination with other neuropeptides or neurotransmitters.
    • Their release mechanisms differ from classical calcium-dependent exocytosis, facilitating slow synaptic and non-synaptic signaling.
    • Coexistence and co-storage throughout the central nervous system enable complex pre- and post-synaptic interactions.

    Conclusions:

    • Subcellular storage sites and sorting mechanisms are critical for neuropeptide release modes.
    • Neuropeptide storage and release dynamics dictate their function as versatile neuronal messengers.
    • Understanding these processes is key to deciphering complex neural circuit functions.