Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabotropic glutamate receptors.

Francesco Ferraguti1, Ryuichi Shigemoto

  • 1Department of Pharmacology, Innsbruck Medical University, Peter Mayr Strasse 1a, A-6020, Innsbruck, Austria.

Cell and Tissue Research
|July 19, 2006
PubMed
Summary

Metabotropic glutamate receptors (mGluRs) are crucial for brain function. This review details their distribution and functional implications in the central and peripheral nervous systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle Regeneration Failure May Lead to Clinical Features of Myopathy in Anti-IgLON5 Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

A multitransmitter, synaptic specification-segregated calyx-like synapse linking pontine pituitary adenylate cyclase-activating polypeptide neurons to forebrain-extended amygdala.

PNAS nexus·2026
Same author

Distribution and functional significance of rodent cerebellar glycogen.

iScience·2026
Same author

Developmental regulation of GABA<sub>B</sub> receptors and downstream molecules in the mouse brain.

Histology and histopathology·2025
Same author

Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks.

Nature neuroscience·2024
Same author

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons.

PLoS biology·2024

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors activated by glutamate.
  • Eight mGluR subtypes (mGlu1-8) exist, with further diversity from alternative splicing.
  • mGluRs regulate neuronal excitability, synaptic plasticity, and neurotransmitter release.

Purpose of the Study:

  • To review anatomical findings on mGluR distribution in the central nervous system (CNS).
  • To examine recent evidence on mGluR localization in peripheral tissues.
  • To discuss the regional, cellular, and subcellular distribution of mGluRs in relation to function.

Main Methods:

  • Review of anatomical studies on mGluR distribution.
  • Analysis of molecular cloning data for mGluR subtypes.
  • Examination of pharmacological properties and signaling pathways.

Main Results:

  • Detailed summary of mGluR distribution across the CNS.
  • Inclusion of data on mGluR localization in peripheral tissues.
  • Discussion of mGluR distribution relative to neurotransmitter release sites.

Conclusions:

  • mGluR distribution is diverse and specific across the CNS and periphery.
  • Understanding mGluR localization is key to elucidating their functional roles.
  • Further research into mGluR distribution can inform therapeutic strategies.

Related Experiment Videos