Related Experiment Video
Updated: Aug 7, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein
Agnieszka K Olejnik-Schmidt1, Marcin T Schmidt, Anna Goździcka-Józefiak
1Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Poznań, Poland. mschmidt@au.poznan.pl
Abstract:
The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein--a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Regulation of Nuclear Protein Sorting
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RNA Polymerase II Accessory Proteins
RNA Polymerase II Accessory Proteins

