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Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin1, Evaldas Katilius, Yan Liu

  • 1Department of Chemistry and Biochemistry, and The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

Angewandte Chemie (International Ed. in English)
|July 19, 2006
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...