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Updated: May 8, 2026

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
Published on: December 27, 2014
[Three cases report of olfactory cleft disease]
1Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Medical Academy, Beijing, China.
Olfactory cleft disease, a new cause of anosmia (loss of smell), presents with complete obstruction. Medical treatments show poor effectiveness, indicating a need for further research into this olfactory disorder.
Area of Science:
- Otolaryngology
- Neurology
Background:
- Olfactory dysfunction is a common complaint.
- New disease entities impacting olfaction require characterization.
Observation:
- Three patients presented with anosmia.
- Nasal endoscopy revealed complete bilateral olfactory cleft obstruction with mucosal edema.
- Computed tomography (CT) imaging showed soft tissue within the olfactory clefts.
Findings:
- All patients exhibited anosmia confirmed by T&T olfactory testing.
- No olfactory event-related potentials were detected.
- Medical therapy with antibiotics and corticosteroids yielded minimal improvement in two patients, with transient improvement in one.
Implications:
- Olfactory cleft disease is identified as a distinct clinical entity causing anosmia.
- Nasal endoscopy and CT are crucial for diagnosis.
- Current medical therapies demonstrate limited efficacy for olfactory cleft disease.
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