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Updated: Aug 7, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Preparation of atenolol monolithic osmotic pump tablets]
Long-Xiao Liu1, Bin-Jie Che, Qing Xu
1Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310027, China. liulx@zju.edu.cn
Aim:
The simplified preparative method and formulation for atenolol monolithic osmotic pump tablets were investigated.
Methods:
The core tablets with an indentation were compressed by the punch with a needle. Osmotic pump tablets were prepared by coating the indented tablets. Similarity factor was used to evaluate formulation of osmotic pump tablets.
Results:
The formulation of core tablets and the composition and thickness of coating membrane showed marked effects on drug release. Orifice size of core tablets in the range of 1.00 - 1.14 mm scarcely affected drug release.
Conclusion:
The preparation of osmotic pump tablets was simplified with the exempting of laser drilling. The atenolol monolithic osmotic pump tablets could deliver drug constantly for 24 h.
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