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Published on: September 12, 2014
Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants
Michel Wathier1, C Starck Johnson, Terry Kim
1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.
Bioconjugate Chemistry
|July 20, 2006
Abstract:
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.
