Related Experiment Video
Updated: Aug 7, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Complex chemical kinetics in single enzyme molecules: Kramers's model with fractional Gaussian noise
Srabanti Chaudhury1, Binny J Cherayil
1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Abstract:
A model of barrier crossing dynamics governed by fractional Gaussian noise and the generalized Langevin equation is used to study the reaction kinetics of single enzymes subject to conformational fluctuations. The direct application of Kramers's flux-over-population method to this model yields analytic expressions for the time-dependent transmission coefficient and the distribution of waiting times for barrier crossing. These expressions are found to reproduce the observed trends in recent simulations and experiments.
Related Concept Videos
Introduction to Enzyme Kinetics
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
Enzyme Kinetics
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Reaction Mechanisms: The Steady-State Approximation
Multi-Step Reactions
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Reaction Mechanisms: Rate-limiting Step Approximation

