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Current developments using emerging transdermal technologies in physical enhancement methods.

A Nanda1, S Nanda, N M Khan Ghilzai

  • 1Faculty of Pharm. Sci., M.D. University, Rohtak, Haryana 124001, India. an_mdu@rediffmail.com

Current Drug Delivery
|July 20, 2006
PubMed
Summary
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Physical methods enhance transdermal drug delivery by overcoming the skin barrier. Emerging technologies like microneedles and jet injectors offer innovative solutions for drug administration.

Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Transdermal drug delivery offers advantages but faces limitations due to the stratum corneum barrier.
  • Physical methods are increasingly utilized to enhance drug permeation through the skin.
  • Commercial development of physical transdermal delivery devices is rapidly advancing.

Purpose of the Study:

  • To review recent commercial developments in physical transdermal drug delivery technologies.
  • To highlight specific devices and applications targeted by the pharmaceutical industry.
  • To provide an overview of innovative approaches overcoming the skin barrier.

Main Methods:

  • Microporation technologies (Macroflux, MTS, Silex) using microneedles.

Related Experiment Videos

  • Needleless jet injectors (Intraject, Powderject, Helios) for particulate drug delivery.
  • Other physical methods including modified tattoos, heat (CHADD), lasers, ultrasound (Sonophoresis), modified liposomes, magnetic fields, and iontophoresis (Dupel, Ionzyme, etc.).

    • Main Results:

    • Various physical methods demonstrate potential for enhanced transdermal drug delivery.
    • Commercial devices are emerging for applications like drug administration and non-invasive monitoring (e.g., GlucoWatch).
    • These technologies aim to bypass or transiently disrupt the stratum corneum barrier.

    Conclusions:

    • Physical transdermal drug delivery technologies are maturing with significant commercial interest.
    • Innovations in microneedles, jet injectors, and other physical methods offer promising alternatives to conventional delivery.
    • The pharmaceutical industry is actively exploring these advanced physical methods for diverse therapeutic applications.